Micky van de Ven Brace Ends Everton's Run at New Stadium
The Dutch defender emerged as the first defender to score two goals in a English top-flight match for Spurs since the Belgian defender in spring 2013.
At a glance
The Spurs defender nods home two times in opening period
The home side's defender has equalizer disallowed after VAR review
Pape Matar Sarr nets final goal in 89th minute
This loss is the Merseyside club's first at their new ground
The Tottenham defender scored twice as Tottenham extended their unbeaten run on the road in the top division and handed Everton their initial loss at Hill Dickinson Stadium.
The Toffees were undefeated in their five previous fixtures at their new ground at the dockside location, having left their historic home behind after 133 years at the end of last season.
But Spurs captain Van de Ven pounced on two occasions from corners in the first half to place their strong form at jeopardy, and they were failed to mount a comeback before Pape Matar Sarr - set up by former Toffees attacker the Brazilian - nodded in a final goal to seal the victory.
The Everton defender thought he had levelled the scores a short while after the defender's first goal, glancing a bullet header past the Spurs keeper from an Everton corner.
Beto, meanwhile, failed to convert a number of opportunities, while Vicario made a series of excellent saves to guarantee Tottenham went five away games without defeat in the Premier League.
But the VAR intervened, advising Craig Pawson to review the goal on the pitchside monitor and the referee ruled that the winger and Iliman Ndiaye were in offside positions and had impeded with the Spurs keeper.
The win moves Thomas Frank's side into third place in the division, a handful of points off north London rivals and table-toppers Arsenal.
The Merseyside club remain 14th and sit half a dozen points clear of the drop zone.
Tottenham analysis: Van de Ven excels in role at both ends of the field
Following a uninspiring midweek performance in the Champions League against Monaco, where they mustered a only attempts on target, the manager opted for the French striker up front instead of ex-Everton forward the Brazilian.
The new arrival was failed to influence the game before being replaced for Richarlison after an hour on the pitch, but it emerged he wasn't needed in the final outcome.
Defender Van de Ven converted into an offensive threat to be reckoned with.
Tottenham's first goal came from a well-worked corner routine, with the midfielder directing the ball back across the six-yard box for an free Van de Ven to head home.
And the captain - stepping up as captain in Cristian Romero's unavailability - added his second in added time as he outjumped the England keeper to head home.
Van de Ven was just as impressive in defensive duties, partnering well with Kevin Danso as the pair handled excellently with the numerous deliveries thrown their way by Everton.
Everton analysis: Everton missing striker's instinct
The club's recent stadium had been a fortress, but it seems the freshness may have worn off somewhat and supporters flocked to the exits after the midfielder's third for Tottenham.
The end in the team's unbeaten home run will not be a massive worry for the manager, but their striker situation are.
The forward and Thierno Barry - the Everton's two established centre-forwards - had scored only a single goal combined before Sunday's match.
And they were unable to contribute to that miserable record on a wet and gloomy night on in Liverpool.
Beto's form was summed up when he chose to bicycle-kick a golden opportunity from near the goal, despite having space and opportunity to readjust for a more conventional attempt that would have challenged Vicario.
The substitute, too, failed to influence the game after coming on for the starter in the second half.
It was not for a shortage of chance. Most of Everton's offensive moves came through Grealish and the forward, who tirelessly whipped dangerous balls into the Spurs penalty area.
Upcoming fixtures for both teams?
The Toffees: The team travel to Sunderland in the Premier League on Monday, 3 November at 8 PM.
Spurs: Spurs travel to Newcastle's ground on late October for their fourth-round Carabao Cup tie against the Magpies.